The Snyder Lab's research goal is to identify the role of adult neurogenesis in memory and stress-related behaviours. We inhibit neurogenesis with transgenic animals in order to understand how they contribute to these behaviours, viral tools for labelling and modifying neurons, immunohistochemistry to quantify and characterize the neurogenesis process, and in vitro electrophysiology to understand the circuit mechanisms by which these new neurons regulate behaviour. The neurobiology of behaviour extends far beyond adult neurogenesis, however, and so we are also generally interested in how neurons throughout the dentate gyrus, hippocampus, and related structures interact to guide behaviour.
I’m excited about the science but I’m also excited about doing it in the open. Discoveries exist well before they’re printed in a journal but in most cases people don’t appreciate this, since discoveries are rarely shared as they happen. The lab website is under construction and I plan to do things a little differently and get our science out in the open. Early. To assist others and stimulate discussion. I’d like to see undergrads in my lab have their data available online in a citable format. You don’t need a peer-reviewed publication or a graduate degree to contribute something valuable to the scientific record.
Get in touch if you are interested in joining the lab.
Seib DR, Espinueva, D, Princz-Lebel O, Chahley E, Floresco SB, Snyder JS (2018) Hippocampal neurogenesis promotes preference for future rewards.
Cahill SP, Cole JD, Yu RQ, Clemans-Gibbon J, Snyder JS (2018) Differential effects of extended exercise and memantine treatment on adult neurogenesis in male and female rats. Neuroscience, 390: 241-255.
Seib DR, Chahley E, Princz-Lebel O, Snyder JS (2018) Intact memory for local and distal cues in male and female rats that lack adult neurogenesis. PLoS ONE, 13(5): e0197869.
Snyder JS (2018) Questioning human neurogenesis. Nature, 555: 315-6.
Todorova EV, Cahill SP, O’Leary TP, Snyder JS (2017) Stressful experiences differentially regulate immediate-early genes and stress hormones receptors in immature and mature dentate gyrus neurons. Matters Select 10.19185/matters.201710000009.
Cahill SP, Yu RQ, Green DC, Todorova EV, Snyder JS (2017) Early survival and delayed death of developmentally-born dentate gyrus neurons. Hippocampus, 27:1155-1167.
For a full list of publications, visit the Snyder Lab.
- Michael Smith Foundation for Health Research Scholar Award (2014)
- Canadian Institutes of Health Research New Investigator Award (2013)