Greater sensitivity to novelty in rats is associated with increased motor impulsivity following repeated exposure to a stimulating environment: implications for the etiology of impulse control deficits



Authors: Jacqueline-Marie N. Ferland, Fiona D. Zeeb, Katrina Yu, Sukhbir Kaur, Matthew D. Taves, Catharine A. Winstanley
Publication: European Journal of Neuroscience PMID: 25308904
Abstract: Heightened motor impulsivity and increased novelty-seeking commonly co-occur in psychiatric disorders, including drug addiction. However, the relationship between these two phenomena remains unclear. Using repeated exposure to a novel, stimulating environment, we found that a subgroup of rats that were more sensitive to the environment, ultimately resulting in increased motor impulsivity. These results give us insight into why some individuals may be more reactive in stimulating environments and how this sensitivity may potentially be involved in the precipitation of psychiatric symptoms in impulse control disorders. View paper


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