The lab’s goal is to identify the role of adult neurogenesis in memory and stress-related behaviours. We inhibit neurogenesis with transgenic animals in order to understand how they contribute to these behaviours, viral tools for labelling and modifying neurons, immunohistochemistry to quantify and characterize the neurogenesis process, and in vitro electrophysiology to understand the circuit mechanisms by which these new neurons regulate behaviour. The neurobiology of behaviour extends far beyond adult neurogenesis, however, and so we are also generally interested in how neurons throughout the dentate gyrus, hippocampus, and related structures interact to guide behaviour.
I’m excited about the science but I’m also excited about doing it in the open. Discoveries exist well before they’re printed in a journal but in most cases people don’t appreciate this, since discoveries are rarely shared as they happen. The lab website is under construction and I plan to do things a little differently and get our science out in the open. Early. To assist others and stimulate discussion. I’d like to see undergrads in my lab have their data available online in a citable format. You don’t need a peer-reviewed publication or a graduate degree to contribute something valuable to the scientific record.
Get in touch if you are interested in joining the lab. We are currently (but not necessarily exclusively) looking for an experienced electrophysiologist and individuals with computational and/or programming experience.
Snyder JS, Ferrante SC, Cameron HA (2012) Late Maturation of Adult-Born Neurons in the Temporal Dentate Gyrus. PLOS ONE, 7(11): e48757
Snyder JS, Cameron HA (2012) Could adult hippocampal neurogenesis be relevant for human behavior? Behav. Brain Res. 227: 384-90.
Snyder JS, Clifford M, Jeurling S, Cameron HA (2012) Complementary activation of hippocampal-cortical subregions and immature neurons following chronic training in single and multiple context versions of the water maze. Behav. Brain Res. 227: 330-9.
Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature, 476: 458-61.
Snyder JS, Ramchand P, Rabbett S, Radik R, Wojtowicz JM, Cameron HA (2011) Septo-temporal gradients of neurogenesis and activity in 13-month-old rats. Neurobiol. Aging, 32: 1149-56.
Snyder JS, Choe J, Clifford M, Jeurling S, Hurley P, Brown A, Kamhi J, Cameron HA (2009) Adult-born hippocampal neurons are more numerous, faster maturing and more involved in behavior in rats than in mice. Journal of Neuroscience, 29: 14484-95.
Snyder JS, Glover LR, Sanzone KM, Kamhi JF, Cameron HA (2009) The effects of exercise and stress on the survival and maturation of adult-generated granule cells. Hippocampus 19: 898-906.
Snyder JS, Radik R, Wojtowicz JM, Cameron HA (2009) Anatomical gradients of adult neurogenesis and activity: Young neurons in the ventral dentate gyrus are activated by water maze training. Hippocampus 19: 360-70.
Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16: 296-304.
Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM (2005) A role for adult neurogenesis in long-term memory. Neuroscience 130: 843-52.
Snyder JS, Kee NJ, Wojtowicz JM (2001) Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J. Neurophysiol. 85: 2423-31.
PSYC360 Biopsychology Sections
The relationship between the nervous system and behaviour; the physiological basis of perception, motivation, learning, and memory. Please consult the Faculty of Science Credit Exclusion List: www.students.ubc.ca/calendar/index.cfm?tree=12,215,410,414.
One fine body…