Dr. Paula Duarte-Guterman is a postdoctoral research fellow at the University of British Columbia in the laboratory of Dr. Liisa Galea. She completed her PhD at the University of Ottawa investigating the interactions of thyroid and sex steroid hormones during frog development. She then completed a postdoctoral fellowship at the University of Ulm, Germany, probing the neuroendocrine mechanisms of paternal care in mice.
Duarte-Guterman is interested in how hormones and experiences affect brain and behaviour. and specifically is investigating how hormones (estrogens and androgens, and peptides such as oxytocin) regulate the production of new neurons (neurogenesis) in the hippocampus. She is currently funded by The Alzheimer’s Association to investigate the short and long-term effects of motherhood on brain and cognition.
Galea LAM, Roes MM, van den Brink C, Lieblich S; Mahmoud R, Chow C, Duarte-Guterman P. 2018. Premarin has opposing effects on spatial learning, neural activation and serum cytokine levels in middle age dependent on reproductive history. Neurobiology of Aging, 70:291-307
Galea LAM, Qiu W, Duarte-Guterman P. Beyond sex differences: Short and long-term implications of motherhood on women's health. Current Opinion in Physiology, 6:82-88.
Swift-Gallant A*, Duarte-Guterman P*, Hamson DK, Ibrahim M, Monks DA, Galea LAM. 2018. Neural androgen receptors affect the number of surviving new neurons in the adult dentate gyrus of male mice. Journal of Neuroendocrinology, 30(4):e12578 * Co-first authors.
Galea LA and Duarte-Guterman P. 2016. Hormones and the regulation of adult neurogenesis in the hippocampus and beyond: Where are we now? Introduction to the special issue on hormonal regulation of adult neurogenesis: Implications for disease. Frontiers in Neuroendocrinology, 41:1-2.
Duarte-Guterman P, Yagi S, Chow C, Galea LAM. 2015. Hippocampal learning, memory, and neurogenesis: effects of sex and estrogens across the lifespan in adults. Hormones and Behavior, 74:37-52.
Duarte-Guterman P, Lieblich SE, Chow C, Galea LAM. 2015. Estradiol and GPER activation differentially affect cell proliferation but not GPER expression in the hippocampus of adult female rats. PLOS ONE, 10(6):e0129880.
Duarte-Guterman P, Navarro-Martin L, Trudeau VL. 2014. Mechanisms of crosstalk between endocrine systems: regulation of sex steroid hormone synthesis and action by thyroid hormones. General and Comparative Endocrinology, 203:69-85.
Galea LAM, Wainwright SR*, Roes MM*, Duarte-Guterman P*, Chow C*, Hamson DK*. 2013. Sex, hormones, and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications. Journal of Neuroendocrinology 25(11):1039-1061. * Contributed equally.
- Young Investigatory Award, Parental Brain Conference, Toronto, Canada. (2018)
- Alzheimer’s Association Research Fellowship co-funded by the Brain Canada Foundation (2017-2020)
- Postdoctoral fellowship, Natural Sciences and Engineering Research Council of Canada (2012-2014)
- Postdoctoral fellowship, Fonds Québécois de la Recherche sur la Nature et les Technologies (declined second year) (2011-2013)