Dr. Jef frey Mogil - E.P. Taylor Professor of Pain Studies\, CRC Chair in the Genet ics of Pain (Tier I)\, Director\, Alan Edwards Centre for Research on Pain\ , McGill University\, Montreal\, QC
Pain in Mice and Me n: Ironic Adventures in Translation
Recent decades h ave seen an explosion in our understanding of the molecular and cellular un derpinnings of pain\, but virtually none of this knowledge has resulted in new clinical therapies. The first part of the talk will explore the reasons for this lack of translation\, including a mismatch between clinical chara cteristics and preclinical experimental design choices\, species-specific g ene expression\, and emerging challenges in clinical trials. The second par t of the talk will focus on recent studies in our laboratory concerning the modulation of pain by social factors. One would imagine these would be eve n harder to translate into humans\, but in this domain translation between mice and undergraduates has been surprisingly successful. These observation s collectively challenge assumptions commonly made about the biopsychosocia l model\, and have important philosophical implications for animal research .
This event is jointly sponsored by the British Columbia Pain Re search Network and UBC's Department of Psychology.
< a href="https://www.mcgill.ca/psychology/jeffrey-mogil" target="_blank" rel ="noopener">Dr. Jeffrey Mogil is interested in nervous system mechanism s mediating the perception and inhibition of pain. Pain is a complex\, subj ective experience that displays considerable variability compared to other sensory modalities. In some instances and in some people\, intensely noxiou s stimuli are not reported as causing pain\, whereas others can experience excruciating pain from light touching of the skin. Some people are highly s ensitive to pain relief from placebo administration\, while others are inse nsitive to even high doses of morphine. Research is focused on uncovering a nd explaining sources of variability in these phenomena. Dr. Mogil uses a m ultidisciplinary approach ranging from molecular gene mapping to the develo pment of new behavioural models. Recent experiments have uncovered surprisi ng and intriguing social effects on pain behaviours in mice\, and much curr ent work in the laboratory is aimed at understanding these.
Ann ually the Department of Psychology hosts a Colloquia Series throughout the academic year.
LOCATION:Earth Sciences Building\, Room 1012 GEO:49.262848;-123.251892 URL;VALUE=URI:https://psych.ubc.ca/events/event/psychology-colloquium-dr-je ffrey-mogil-mcgill-university/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Vancouver BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 DTSTART:20180311T100000 TZNAME:PDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR